In recent years, the biological activities and synthesis methods of amantadine derivatives have been further studied. SAXAGLIPTIN is a highly effective, selective, and competitive dipeptidyl peptidase IV (DPP-IV) inhibitor for the treatment of type 2 diabetes mellitus in adults. 1-Adamantane Carboxaldehyde can be used as the main raw material for the synthesis of saxagliptin.
It is generally believed that the functional groups of aldehydes are unstable and it is difficult to obtain high yield products through the usual oxidation reaction.The oxidants reported in the literature are relatively mild, but PCC oxidation pollutes the environment with heavy metal chromium, and the concentration of effective oxidant for TEMPO-oxidation is low, and 1-Adamantane methanol, which is difficult to prepare, is used as the raw material, so the industrial production is difficult.Our organic synthesizers can synthesize 1-Adamantane Carboxaldehyde in a safe, economical and green way under mild reaction conditions.
1, 8-Bis (Dimethylamino)Naphthalene
Carboxylic acids and their derivatives are widely found in natural products and drug molecules.
The structural modification of these organic small molecule skeletons provides new opportunities for the design and synthesis of innovative drugs. 1, 8-Bis (Dimethylamino)Naphthalene can be used to synthesize carboxylic acid derivatives.In addition, in the reaction of preparing the key intermediate of ERB-2, the appropriate amount of Mn powder was creatively added to the reaction system, and the combination of Cr3+ and ligand and 1, 8-Bis (Dimethylamino)Naphthalene could significantly reduce the amount of chromium reagent and improve the reaction yield.
Disucinimidy Suberate is a membrane-permeable bifunctional cross-linking agent and a non-cleaved ADC linker, which can be used for the synthesis of antibody drug coupling drugs (ADCs) and can be used to improve the activity of broken DNA.